Shell Versus Core Architecture and Biology of Thrombi in Acute Ischemic Stroke: A Systematic Review.

ABSTRACT:

Background

The presence of an outer shell has been recently described as a common feature of acute ischemic stroke (AIS) thrombi. We performed a systematic review of the current literature on shell genesis, structure, and clinical significance.

Methods

Following PRISMA guidelines, we searched Ovid Cochrane Central Register of Controlled Trials, Embase, Medline, Scopus, and Web of Science for studies reporting the composition and structure of AIS thrombi and clot analogs. Identified studies were added to Covidence software for primary screening. Two reviewers independently screened titles and abstracts followed by full-text screening.

Results

From 1290 identified studies, 10 were included in this review. Studies using histology/immunohistochemistry/immunofluorescence d

SUBMITTER: Mereuta OM 

PROVIDER: S-EPMC10647960 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature