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PKCδ regulates the vascular biology in diabetic atherosclerosis.


ABSTRACT: Diabetes mellitus, known for its complications, especially vascular complications, is becoming a globally serious social problem. Atherosclerosis has been recognized as a common vascular complication mechanism in diabetes. The diacylglycerol (DAG)-protein kinase C (PKC) pathway plays an important role in atherosclerosis. PKCs can be divided into three subgroups: conventional PKCs (cPKCs), novel PKCs (nPKCs), and atypical PKCs (aPKCs). The aim of this review is to provide a comprehensive overview of the role of the PKCδ pathway, an isoform of nPKC, in regulating the function of endothelial cells, vascular smooth muscle cells, and macrophages in diabetic atherosclerosis. In addition, potential therapeutic targets regarding the PKCδ pathway are summarized. Video Abstract.

SUBMITTER: Qin P 

PROVIDER: S-EPMC10652453 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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PKCδ regulates the vascular biology in diabetic atherosclerosis.

Qin Peiliang P   He Changhuai C   Ye Pin P   Li Qin Q   Cai Chuanqi C   Li Yiqing Y  

Cell communication and signaling : CCS 20231116 1


Diabetes mellitus, known for its complications, especially vascular complications, is becoming a globally serious social problem. Atherosclerosis has been recognized as a common vascular complication mechanism in diabetes. The diacylglycerol (DAG)-protein kinase C (PKC) pathway plays an important role in atherosclerosis. PKCs can be divided into three subgroups: conventional PKCs (cPKCs), novel PKCs (nPKCs), and atypical PKCs (aPKCs). The aim of this review is to provide a comprehensive overview  ...[more]

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