Oxytocinergic projection from the hypothalamus to supramammillary nucleus drives recognition memory in mice.

ABSTRACT: Oxytocin (OXT) neurons project to various brain regions and its receptor expression is widely distributed. Although it has been reported that OXT administration affects cognitive function, it is unclear how endogenous OXT plays roles in cognitive function. The present study examined the role of endogenous OXT in mice cognitive function. OXT neurons were specifically activated by OXT neuron-specific excitatory Designer Receptors Exclusively Activated by Designer Drug expression system and following administration of clozapine-N-oxide (CNO). Object recognition memory was assessed with the novel object recognition task (NORT). Moreover, we observed the expression of c-Fos via immunohistochemical staining to confirm neuronal activity. In NORT, the novel object exploration time percentage signi

SUBMITTER: Takahashi J 

PROVIDER: S-EPMC10653413 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature