A low-fat diet improves fatigue in multiple sclerosis: Results from a randomized controlled trial.

ABSTRACT:

Background

Fatigue can be a disabling multiple sclerosis (MS) symptom with no effective treatment options.

Objective

Determine whether a low-fat diet improves fatigue in people with MS (PwMS).

Methods

We conducted a 16-week randomized controlled trial (RCT) and allocated PwMS to a low-fat diet (active, total daily fat calories not exceeding 20%) or wait-list (control) group. Subjects underwent 2 weeks of baseline diet data collection (24-hour diet recalls (24HDRs)), followed by randomization. The active group received 2 weeks of nutrition counseling and underwent a 12-week low-fat diet intervention. One set of three 24HDRs at baseline and week 16 were collected. We administered a food frequency questionnaire (FFQ) and Modified Fatigue Impact Scale (MFIS) every 4 weeks

SUBMITTER: Chase E 

PROVIDER: S-EPMC10655900 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature