Mechanosensitive ion channel Piezo1 mediates mechanical ventilation-exacerbated ARDS-associated pulmonary fibrosis.

ABSTRACT:

Introduction

Pulmonary fibrosis is a major cause of the poor prognosis of acute respiratory distress syndrome (ARDS). While mechanical ventilation (MV) is an indispensable life-saving intervention for ARDS, it may cause the remodeling process in lung epithelial cells to become disorganized and exacerbate ARDS-associated pulmonary fibrosis. Piezo1 is a mechanosensitive ion channel that is known to play a role in regulating diverse physiological processes, but whether Piezo1 is necessary for MV-exacerbated ARDS-associated pulmonary fibrosis remains unknown.

Objectives

This study aimed to explore the role of Piezo1 in MV-exacerbated ARDS-associated pulmonary fibrosis.

Methods

Human lung epithelial cells were stimulated with hydrochloric acid (HCl) followed by mechanical

SUBMITTER: Fang XZ 

PROVIDER: S-EPMC10658225 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature