The Effects of Age, Gender, and Postvoid Residual Volume on Catheterization Rates After Treatment with OnabotulinumtoxinA for Overactive Bladder.

ABSTRACT:

Background

Transient increases in postvoid residual urine volume (PVR) requiring clean intermittent catheterization (CIC) have occurred with onabotulinumtoxinA treatment for overactive bladder (OAB).

Objective

To evaluate onabotulinumtoxinA safety and the effect of age, gender, and maximum PVR (PVR_max) on CIC initiation in adults with OAB and urinary incontinence (UI).

Design setting and participants

This was a pooled post hoc analysis of four placebo-controlled, multicenter randomized trials that included adults with idiopathic OAB after first onabotulinumtoxinA treatment (NCT00910845, NCT00910520, NCT01767519, NCT01945489). Patients had at least three urgency UI episodes over 3 d and at least eight micturitions per day, had inadequate management with at l

SUBMITTER: Dmochowski R 

PROVIDER: S-EPMC10658411 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature