The potential clinical impact of cell type-specific genetic regulation: Crohn's disease.

ABSTRACT: Complex diseases are heterogenous due to variation in their genetic and environmental underpinnings, leading to varied treatment responses. Genome-wide association studies (GWAS) integrated with single-cell expression quantitative trait loci analyses (eQTL) can pinpoint cell-type specific candidate disease-relevant genes and pathways. This knowledge can be applied to patient stratification and novel therapeutic target identification. Here, we describe the translational potential of cell-type specific genetic regulation, using Crohn's disease as an example.

SUBMITTER: Tyebally R 

PROVIDER: S-EPMC10659767 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature