Effects of acute aerobic exercise on circulating sTLR and sRAGE profiles in normal- and abnormal-glucose-tolerant individuals.

ABSTRACT: BMI-matched normal- (NGT, n = 10, 41 ± 4y, 35.6 ± 3.0 kg/m² ) and abnormal-glucose-tolerant (AGT, n = 16, 51 ± 3y, 34.3 ± 1.5 kg/m² ) participants were evaluated for body composition, metabolic health (oral glucose tolerance test [OGTT]), and VO₂ max. Participants also completed a treadmill walking test at 65% VO₂ max for 30 min. Total sRAGE, esRAGE, sTLR2, and sTLR4 were assessed via ELISA, and cRAGE was calculated. AGT exhibited greater (p < 0.05) body fat % (+24%), fasting plasma glucose (+37%), OGTT AUC (+59%), and HOMA-IR (+55%) and lower (p < 0.05) VO₂ max (-24%). sTLR2 was 33% lower in AGT than NGT (main effect, p = 0.034). However, sTLR2 did not change (p > 0.05) following AE. sTLR4 tended to be 36% lower in AGT than NGT (main

SUBMITTER: Perkins RK 

PROVIDER: S-EPMC10659941 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature