Dataset Information

The mycological efficacy and safety of selenium sulfide 1.8% versus ketoconazole 2% shampoo in pityriasis versicolor: A double-blind randomized controlled trial.

ABSTRACT:

Introduction

Although it has long been used as a topical treatment of pityriasis versicolor (PV), the efficacy of topical selenium disulfide as compared to topical ketoconazole in the treatment of PV remains unclear. This study aims to assess the mycological efficacy and safety of SeS₂ 1.8% shampoo and ketoconazole 2% shampoo for the treatment of PV.

Methods

A double-blind randomized controlled trial was performed in patients with PV during September-December 2018, based on block randomization. Physical examinations, scale provocation test, Wood's lamp, and potassium hydroxide examination were conducted. Intention to treat analysis was performed to evaluate the mycological efficacy.

Results

The mycological efficacy and side effect were not significantly different between the ketoconazole group and the selenium group; 94% vs 86% (RR=2.3(95%CI 0.6-8.5), p=0.182), and 22% versus 8%.

Conclusions

SeS2 1.8% has the same mycological efficacy and side effect as compared to ketoconazole 2% in the treatment of PV.

SUBMITTER: Lusiana

PROVIDER: S-EPMC10660221 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Publications

The mycological efficacy and safety of selenium sulfide 1.8% versus ketoconazole 2% shampoo in pityriasis versicolor: A double-blind randomized controlled trial.

Lusiana Surachmiati Lis L Saldi Siti Rizny Fitriana SRF Lusianingtyas Trah T Bramono Kusmarinah K

Germs 20221231 4

<h4>Introduction</h4>Although it has long been used as a topical treatment of pityriasis versicolor (PV), the efficacy of topical selenium disulfide as compared to topical ketoconazole in the treatment of PV remains unclear. This study aims to assess the mycological efficacy and safety of SeS<sub>2</sub> 1.8% shampoo and ketoconazole 2% shampoo for the treatment of PV.<h4>Methods</h4>A double-blind randomized controlled trial was performed in patients with PV during September-December 2018, base ...[more]

PMID: 38021181

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Project description:BackgroundDietary recommendations for selenium differ between countries, mainly because of uncertainties over the definition of optimal selenium status.ObjectiveThe objective was to examine the dose-response relations for different forms of selenium.DesignA randomized, double-blind, placebo-controlled dietary intervention was carried out in 119 healthy men and women aged 50-64 y living in the United Kingdom. Daily placebo or selenium-enriched yeast tablets containing 50, 100, or 200 microg Se ( approximately 60% selenomethionine), selenium-enriched onion meals ( approximately 66% gamma-glutamyl-methylselenocysteine, providing the equivalent of 50 microg Se/d), or unenriched onion meals were consumed for 12 wk. Changes in platelet glutathione peroxidase activity and in plasma selenium and selenoprotein P concentrations were measured.ResultsThe mean baseline plasma selenium concentration for all subjects was 95.7 +/- 11.5 ng/mL, which increased significantly by 10 wk to steady state concentrations of 118.3 +/- 13.1, 152.0 +/- 24.3, and 177.4 +/- 26.3 ng/mL in those who consumed 50, 100, or 200 microg Se-yeast/d, respectively. Platelet glutathione peroxidase activity did not change significantly in response to either dose or form of selenium. Selenoprotein P increased significantly in all selenium intervention groups from an overall baseline mean of 4.99 +/- 0.80 microg/mL to 6.17 +/- 0.85, 6.73 +/- 1.01, 6.59 +/- 0.64, and 5.72 +/- 0.75 microg/mL in those who consumed 50, 100, or 200 microg Se-yeast/d and 50 microg Se-enriched onions/d, respectively.ConclusionsPlasma selenoprotein P is a useful biomarker of status in populations with relatively low selenium intakes because it responds to different dietary forms of selenium. To optimize the plasma selenoprotein P concentration in this study, 50 microg Se/d was required in addition to the habitual intake of approximately 55 microg/d. In the context of established relations between plasma selenium and risk of cancer and mortality, and recognizing the important functions of selenoprotein P, these results provide important evidence for deriving estimated average requirements for selenium in adults. This trial was registered at clinicaltrials.gov as NCT00279812.

Project description:Background and purposePityriasis versicolor (PV) is a common fungal skin infection caused by Malassezia species. Previous studies have shown that the prevalence of PV is influenced by geographic factors. The aim of the current study was to find the epidemiological characteristics of PV and distribution of Malassezia species in the secondary school students living in Hai Phong city, Vietnam.Materials and methodsThis study was conducted on 1357 students within the age range of 10 - 16 years selected from four secondary schools in Hai Phong city. The students were screened for PV skin lesions from August 2016 to December 2017. The isolates of Malassezia from PV patients were analyzed by performing direct microscopy and culturing on modified Dixon agar plates, containing gentamicin, at 32oC for 7 days. In the next stage, the fungal strains obtained from patients with positive fungal cultures were identified using the CHROMagarTM Malassezia medium, polymerase chain reaction-restriction fragment length polymorphism techniques, and D1/D2 rDNA genome sequencing.ResultsPityriasis versicolor was diagnosed in 305 (22.48%) students and confirmed by clinical appearance and direct examination. A total of 293 (96.07%) samples grew on modified Dixon agar. With regard to demographic characteristics, 50.49% of the PV cases were female, and 57.38% of cases resided in urban areas. Furthermore, 88.52% of the subjects had the illness duration of more than 6 months. Hypopigmented and erythematous skin lesions were also observed in the research participants, with hypopigmentation being the most frequent condition (97.05%). Most of the Malassezia fungal strains were isolated from the back (39.56%), face (23.99%), and chest (16.51%). Malassezia furfur and M. japonica accounted for PV in 96.25% and 3.75% of the cases, respectively. Furthermore, Malassezia furfur was distributed in both rural and urban areas, while M. japonica was found only in the urban areas.ConclusionThe findings of the present study were indicative of the high prevalence of Malassezia yeasts, mostly M. furfur, among the students in Hai Phong city, Vietnam.

Dataset Information

The mycological efficacy and safety of selenium sulfide 1.8% versus ketoconazole 2% shampoo in pityriasis versicolor: A double-blind randomized controlled trial.

Introduction

Methods

Results

Conclusions

Publications

The mycological efficacy and safety of selenium sulfide 1.8% versus ketoconazole 2% shampoo in pityriasis versicolor: A double-blind randomized controlled trial.

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