Ex vivo transdermal delivery of ³H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration.

ABSTRACT: Inherent barrier properties of the skin impose significant challenges to the transdermal delivery of drugs to systemic circulation. Here, the ex vivo transdermal permeation and deposition of an anti-malarial prophylactic atovaquone solid drug nanoformulation is radiometrically evaluated following application of a solid microneedle format.

SUBMITTER: Morris S 

PROVIDER: S-EPMC10662085 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature