Hippocampal neurons code individual episodic memories in humans.

ABSTRACT: The hippocampus is an essential hub for episodic memory processing. However, how human hippocampal single neurons code multi-element associations remains unknown. In particular, it is debated whether each hippocampal neuron represents an invariant element within an episode or whether single neurons bind together all the elements of a discrete episodic memory. Here we provide evidence for the latter hypothesis. Using single-neuron recordings from a total of 30 participants, we show that individual neurons, which we term episode-specific neurons, code discrete episodic memories using either a rate code or a temporal firing code. These neurons were observed exclusively in the hippocampus. Importantly, these episode-specific neurons do not reflect the coding of a particular element in the epis

SUBMITTER: Kolibius LD 

PROVIDER: S-EPMC10663153 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature