Reduced Hippocampal-Striatal Interactions during Formation of Durable Episodic Memories in Aging.

ABSTRACT: Encoding of durable episodic memories requires cross-talk between the hippocampus and multiple brain regions. Changes in these hippocampal interactions could contribute to age-related declines in the ability to form memories that can be retrieved after extended time intervals. Here we tested whether hippocampal-neocortical- and subcortical functional connectivity (FC) observed during encoding of durable episodic memories differed between younger and older adults. About 48 younger (20-38 years; 25 females) and 43 older (60-80 years; 25 females) adults were scanned with fMRI while performing an associative memory encoding task. Source memory was tested ~20 min and ~6 days postencoding. Associations recalled after 20 min but later forgotten were classified as transient, whereas memories retai

SUBMITTER: Ness HT 

PROVIDER: S-EPMC9157302 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature