Thalamic Foxp2 regulates output connectivity and sensory-motor impairments in a model of Huntington's Disease.

ABSTRACT:

Background

Huntington's Disease (HD) is a disorder that affects body movements. Altered glutamatergic innervation of the striatum is a major hallmark of the disease. Approximately 30% of those glutamatergic inputs come from thalamic nuclei. Foxp2 is a transcription factor involved in cell differentiation and reported low in patients with HD. However, the role of the Foxp2 in the thalamus in HD remains unexplored.

Methods

We used two different mouse models of HD, the R6/1 and the HdhQ111 mice, to demonstrate a consistent thalamic Foxp2 reduction in the context of HD. We used in vivo electrophysiological recordings, microdialysis in behaving mice and rabies virus-based monosynaptic tracing to study thalamo-striatal and thalamo-cortical synaptic connectivity in R6/1 mice. Micro

SUBMITTER: Rodriguez-Urgelles E 

PROVIDER: S-EPMC10663254 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature