Longitudinal evolution of sleep disturbances in early multiple system atrophy: a 2-year prospective cohort study.

ABSTRACT:

Background

The progression of sleep disturbances remains unclear in patients with early multiple system atrophy (MSA). We aimed to explore the frequency, severity, and coexistence of 2-year longitudinal changes of sleep disturbances including REM sleep behavior disorder (RBD), excessive daytime sleepiness (EDS), and Parkinson's disease-related sleep problems (PD-SP) in early MSA.

Methods

MSA patients with a disease duration < 3 years were enrolled to complete a 2-year follow-up visit. Sleep disturbances including RBD, EDS, and PD-SP were assessed using the RBD Screening Questionnaire, Epworth sleepiness scale, and PD sleep scale-2, respectively.

Results

A total of 220 patients with MSA enrolled in the study and 90 patients completed the 2-year follow-up visit. The sco

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10664599 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature