Cystatin C predicts cognitive decline in multiple system atrophy: A 1-year prospective cohort study.

ABSTRACT:

Background

Accumulating evidence has suggested that cystatin C is associated with cognitive impairment in patients with neurodegenerative diseases. However, the association between cystatin C and cognitive decline in patients with multiple system atrophy (MSA) remains largely unknown.

Objectives

The objective was to determine whether cystatin C was independently associated with cognitive decline in patients with early-stage MSA.

Methods

Patients with MSA underwent evaluation at baseline and the 1-year follow-up. Cognitive function was evaluated with Montreal cognitive assessment (MoCA). Changes in the MoCA score and the absolute MoCA score at the 1-year assessment were considered the main cognitive outcome. The cystatin C concentrations in patients with MSA and age, s

SUBMITTER: Zhang L 

PROVIDER: S-EPMC9742413 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature