[¹⁸F]PSMA-1007 PET is comparable to [^99mTc]Tc-DMSA SPECT for renal cortical imaging.

ABSTRACT:

Background

Scintigraphy using technetium-99m labelled dimercaptosuccinic acid ([^99mTc]Tc-DMSA), taken up in the proximal tubules, is the standard in functional imaging of the renal cortex. Recent guidelines recommend performing [^99mTc]Tc-DMSA scintigraphy with single photon emission computed tomography (SPECT). Prostate-specific membrane antigen (PSMA) targeted positron emission tomography (PET) is used for staging and localization of recurrence in prostate cancer. A high renal uptake is often seen on PSMA PET, concordant with known PSMA expression in proximal tubules. This suggests PSMA PET could be used analogous to [^99mTc]Tc-DMSA scintigraphy for renal cortical imaging. [¹⁸F]PSMA-1007 is a promising radiopharmaceutical for this purpose

SUBMITTER: Valind K 

PROVIDER: S-EPMC10667166 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature