CircTENM3 inhibites tumor progression via the miR-558/RUNX3 axis in prostate cancer.

ABSTRACT:

Background

Prostate cancer (PCa) is currently acknowledged as the second most widespread cancer among men worldwide. Yet, the lack of dependable diagnostic biomarkers and therapeutic targets has presented considerable hurdles to the progression of prostate cancer treatment. Circular RNAs are implicated in the pathogenesis of numerous diseases, positioning them as promising biomarkers for diverse medical conditions. This study aims to uncover a specific circRNA that could serve as a diagnostic and therapeutic target for detecting and treating PCa.

Methods

The change of circTENM3 expression levels in PCa was detected by qPCR. CCK8 assays, EdU assays, Scratch assay and Transwell migration assay conducted to detect the role of circTENM3 in PCa cells in vitro. RIP assay, RNA-pull

SUBMITTER: Lu L 

PROVIDER: S-EPMC10675854 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature