Dataset Information

CircTENM3 inhibites tumor progression via the miR-558/RUNX3 axis in prostate cancer.

ABSTRACT:

Background

Prostate cancer (PCa) is currently acknowledged as the second most widespread cancer among men worldwide. Yet, the lack of dependable diagnostic biomarkers and therapeutic targets has presented considerable hurdles to the progression of prostate cancer treatment. Circular RNAs are implicated in the pathogenesis of numerous diseases, positioning them as promising biomarkers for diverse medical conditions. This study aims to uncover a specific circRNA that could serve as a diagnostic and therapeutic target for detecting and treating PCa.

Methods

The change of circTENM3 expression levels in PCa was detected by qPCR. CCK8 assays, EdU assays, Scratch assay and Transwell migration assay conducted to detect the role of circTENM3 in PCa cells in vitro. RIP assay, RNA-pull down and luciferase reporter assay were performed to explore the mechanism of circTENM3. Gain-of-function analysis was performed to reveal the function of circTENM3 in PCa in vivo.

Results

The results revealed that the expression level of circTENM3 was significantly down-regulated in PCa. CircTENM3 overexpression alleviated the progression of PCa in vitro. Mechanistically, circTENM3 enhanced RUNX3 levels via miR-558 sponge. Gain-of-function analysis determined that circTENM3 overexpression could inhibit PCa progression in vitro.

Conclusions

Our research offers profound insights into the protective role played by circTENM3 in PCa. CircTENM3 operates as a sponge for miR-558, thereby triggering the elevation of RUNX3 expression, which subsequently curbs the progression of PCa.

SUBMITTER: Lu L

PROVIDER: S-EPMC10675854 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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Publications

CircTENM3 inhibites tumor progression via the miR-558/RUNX3 axis in prostate cancer.

Lu Lingxiang L Wang Fei F Chen Jianchun J Zhao Chunchun C Guo Shuai S Dong Da D Jiang Minjun M Huang Yuhua Y

Journal of translational medicine 20231125 1

<h4>Background</h4>Prostate cancer (PCa) is currently acknowledged as the second most widespread cancer among men worldwide. Yet, the lack of dependable diagnostic biomarkers and therapeutic targets has presented considerable hurdles to the progression of prostate cancer treatment. Circular RNAs are implicated in the pathogenesis of numerous diseases, positioning them as promising biomarkers for diverse medical conditions. This study aims to uncover a specific circRNA that could serve as a diagn ...[more]

PMID: 38007527

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Dataset Information

CircTENM3 inhibites tumor progression via the miR-558/RUNX3 axis in prostate cancer.

Background

Methods

Results

Conclusions

Publications

CircTENM3 inhibites tumor progression via the miR-558/RUNX3 axis in prostate cancer.

Similar Datasets

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