Comparison of vaginal microbiota between women with inflammatory bowel disease and healthy controls.

ABSTRACT:

Background

The gut microbiota in patients with inflammatory bowel disease are perturbed in both composition and function. The vaginal microbiome and its role in the reproductive health of women with inflammatory bowel disease is less well described.

Objective

We aim to compare the vaginal microbiota of women with inflammatory bowel disease to healthy controls.

Methods

Women with inflammatory bowel disease enrolled in a longitudinal cohort study provided self-collected vaginal swabs. Healthy controls underwent provider-collected vaginal swabs at routine gynecologic exams. All participants completed surveys on health history, vulvovaginal symptoms and gastrointestinal symptoms, if applicable. Microbiota were characterized by sequencing the V4 region of the 16S rRNA gene

SUBMITTER: Bar O 

PROVIDER: S-EPMC10686494 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature