Kidney function estimators for drug dose adjustment of direct oral anticoagulants in older adults with atrial fibrillation.

ABSTRACT:

Background

The Cockcroft-Gault equation (CrCl_C-G) is recommended for dose adjustment of direct oral anticoagulant drugs (DOACs) to kidney function. We aimed to assess whether defining DOAC dose appropriateness according to various kidney function estimators changed the associations between dose appropriateness and adverse events in older adults with atrial fibrillation (AF).

Methods

Participants of the Berlin Initiative Study with AF and treated with DOACs were included. We investigated CrCl_C-G and estimated glomerular filtration rate (eGFR) using the Chronic Kidney Disease Epidemiology Collaboration and European Kidney Function Consortium equations based on creatinine and/or cystatin C. Marginal structural Cox models yielded confounder-adjusted hazard

SUBMITTER: Villain C 

PROVIDER: S-EPMC10689126 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature