Adding 6-month parameters for the prediction of kidney prognosis in ANCA-associated glomerulonephritis.

ABSTRACT:

Background

Antineutrophil-cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with kidney involvement (AAV-GN) frequently evolves to end-stage kidney disease (ESKD) despite aggressive immunosuppressive treatment. Several risk scores have been used to assess renal prognosis. We aimed to determine whether kidney function and markers of AAV-GN activity after 6 months could improve the prediction of ESKD.

Methods

This retrospective and observational study included adult patients with AAV-GN recruited from six French nephrology centers (including from the Maine-Anjou AAV registry). The primary outcome was kidney survival. Analyses were conducted in the whole population and in a sub-population that did not develop ESKD early in the course of the disease.

Results

When co

SUBMITTER: Boud'hors C 

PROVIDER: S-EPMC10689158 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature