Estimates of the global burden of Congenital Rubella Syndrome, 1996-2019.

ABSTRACT:

Objectives

Many countries introduced rubella-containing vaccination (RCV) after 2011, following changes in recommended World Health Organization (WHO) vaccination strategies and external support. We evaluated the impact of these introductions.

Methods

We estimated the country-specific, region-specific, and global Congenital Rubella Syndrome (CRS) incidence during 1996-2019 using mathematical modeling, including routine and campaign vaccination coverage and seroprevalence data.

Results

In 2019, WHO African and Eastern Mediterranean regions had the highest estimated CRS incidence (64 [95% confidence intervals (CI): 24-123] and 27 [95% CI: 4-67] per 100,000 live births respectively), where nearly half of births occur in countries that have introduced RCV. Other regions,

SUBMITTER: Vynnycky E 

PROVIDER: S-EPMC10689248 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature