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A domino reaction for the synthesis of pyrrolo[2,1-a]isoquinolines from 2-aryl-pyrrolidines and alkynes promoted by a four-component catalytic system under aerobic conditions.

ABSTRACT: Pyrrolo[2,1-a]isoquinoline derivatives were synthesized from 2-aryl-pyrrolidines and alkynes via an oxidative dehydrogenation/cyclization coupling/dehydrogenative aromatization domino process. This reaction was promoted by a four-component catalytic system which included [RuCl2(p-cymene)]2, CuCl, copper acetate monohydrate and TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxy) under aerobic conditions.

SUBMITTER: Luo Z 

PROVIDER: S-EPMC10698731 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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A domino reaction for the synthesis of pyrrolo[2,1-<i>a</i>]isoquinolines from 2-aryl-pyrrolidines and alkynes promoted by a four-component catalytic system under aerobic conditions.

Luo Zheng Z   Hu Huayou H   Wang Chao C   Yang Zhen Z   Wang Yefei Y  

RSC advances 20231101 50

Pyrrolo[2,1-<i>a</i>]isoquinoline derivatives were synthesized from 2-aryl-pyrrolidines and alkynes <i>via</i> an oxidative dehydrogenation/cyclization coupling/dehydrogenative aromatization domino process. This reaction was promoted by a four-component catalytic system which included [RuCl<sub>2</sub>(<i>p</i>-cymene)]<sub>2</sub>, CuCl, copper acetate monohydrate and TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxy) under aerobic conditions. ...[more]

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