New insight into the causal relationship between Graves' disease liability and drug eruption: a Mendelian randomization study.

ABSTRACT:

Background

Graves' disease (GD) and drug eruption are closely associated and frequently observed in the clinical setting. However, it remains unclear whether a causal relationship exists between these two conditions. The aim of the study is to investigate whether GD is causal to drug eruptions using two-sample Mendelian randomization.

Methods

We launched a two-sample MR to investigate whether GD is causal to drug eruption using Genome-wide association study (GWAS) summary data from Biobank Japan and FinnGen. Genetic variants were used as instrumental variables to avoid confounding bias. Statistical methods including inverse variance weighted (IVW), weighted median, MR-Egger, and MR-PRESSO were conducted to identify the robustness of the causal effect.

Results

Genetica

SUBMITTER: Wu D 

PROVIDER: S-EPMC10703291 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature