A multidimensional social risk atlas of depression and anxiety: An observational and genome-wide environmental interaction study.

ABSTRACT:

Background

Mental disorders are largely socially determined, yet the combined impact of multidimensional social factors on the two most common mental disorders, depression and anxiety, remains unclear.

Methods

We constructed a polysocial risk score (PsRS), a multidimensional social risk indicator including components from three domains: socioeconomic status, neighborhood and living environment and psychosocial factors. Supported by the UK Biobank cohort, we randomly divided 110 332 participants into the discovery cohort (60%; n = 66 200) and the replication cohort (40%; n = 44 134). We tested the associations between 13 single social factors with Patient Health Questionnaire (PHQ) score, Generalized Anxiety Disorder Scale (GAD) score and self-reported depression and anxiety.

SUBMITTER: Pan C 

PROVIDER: S-EPMC10704948 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature