The functional and molecular impact of triamcinolone acetonide on primary human bone marrow mesenchymal stem cells.

ABSTRACT: Traumatic or degenerative joint pain is abundant in the population. Symptom relief by intra- and periarticular glucocorticoid administration is frequently used, however may have potentially devastating effects, changing the normal healing process of the joint. Mesenchymal stem cells (MSCs) are important for wound-healing processes due to their multipotency in regenerating osteoblasts, chondrocytes and adipocytes but also have immunomodulatory properties. The aim of this study was to investigate the impact of triamcinolone acetonide (TA) a common glucocorticoid administrated intra- and periarticularly, on human bone marrow derived MSC viability, functionality, multi-lineage differentiation and transcriptomic output. We found that TA treatment induced apoptosis and promoted adipogenesis whil

SUBMITTER: Kumlin M 

PROVIDER: S-EPMC10709330 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature