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Functional and molecular impact of triamcinolone acetonide on primary human bone marrow mesenchymal stem cells

ABSTRACT: Joint pain, either traumatic or degenerative, is a common cause of morbidity. Triamcinolone acetonide (TA), a common glucocorticoid, has been used as symptomatic treatment for joint pain for decades. However, besides its relatively short-lived therapeutic effects, TA may have potentially devastating effects by altering the normal healing process to restore and maintain the cellular entities that contribute to tissue regeneration of the synovial joint. Mesenchymal stem cells (MSCs) have been shown to hold great potential in tissue regeneration due to their multipotency in regenerating osteoblasts, chondrocytes and adipocytes and their immunomodulatory properties. So far, it remains largely unclear how TA treatment affects MSC activities.

ORGANISM(S): Homo sapiens

PROVIDER: GSE240387 | GEO | 2024/01/02

REPOSITORIES: GEO

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