Characterization of the cellular heterogeneity and bone regenerative potential of cultured human periosteal cells.

ABSTRACT:

Introduction

Cell-based bone regenerative therapy exhibits considerable potential in the treatment of bone defects caused by trauma, disease, and congenital anomalies. The periosteum, a fibrous membrane covering the outer surface of bone, plays a crucial role in bone formation and regeneration by sourcing osteoprogenitor cells. The remarkable osteogenic potential of periosteal cells (PCs) has led to the effective clinical implementation of PC-based regenerative therapies and tissue engineering. The abundance of progenitor cells in cultured PCs is well established; however, the heterogeneity of the cell population and its impact on bone regeneration remain uncertain. In this study, we aimed to characterize the heterogeneity of cultured PCs via single-cell RNA-sequencing (scRNA-seq)

SUBMITTER: Tsuzuno T 

PROVIDER: S-EPMC10709511 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature