Statistical optimization and gamma irradiation on cephalosporin C production by Acremonium chrysogenum W42-I.

ABSTRACT: Most antibiotics now used in clinical practice are cephalosporins. Acremonium (A.) chrysogenum W42-I is an intermediate strain out of W42 strain improvement program whose productivity is above that of the wild-type strain to produce the broad-spectrum antibacterial cephalosporin C (CPC). As a result, fermentation process optimization is considered because it offers the ideal environment for strains to reach their full potential. Our research aimed to combine a rational design to regulate the fermentation process environment and culture media as well as to develop mutants with high productivity. Different media were tested to obtain maximum CPC production. To maximize the production of CPC, some environmental parameters were experimentally optimized via the Box-Behnken design used for respo

SUBMITTER: Ibrahim AA 

PROVIDER: S-EPMC10713967 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature