Value of human epididymis secretory protein 4 in differentiating malignant from benign pleural effusion: an analysis of two cohorts.

ABSTRACT:

Background

Lung cancer is the most common cause of malignant pleural effusion (MPE). Serum human epididymis secretory protein 4 (HE4) is a useful diagnostic marker for lung cancer.

Objective

This study aimed to evaluate the diagnostic accuracy of pleural fluid HE4 for MPE.

Design

A prospective, double-blind diagnostic test accuracy study.

Methods

Patients with undiagnosed pleural effusion were enrolled in two cohorts (Hohhot and Changshu). Electrochemiluminescence immunoassay was used to detect pleural fluid HE4. The diagnostic accuracy of HE4 was evaluated by a receiver operating characteristic (ROC) curve, and the net benefit of HE4 was assessed by a decision curve analysis (DCA).

Results

A total of 66 MPEs and 86 benign pleural effusions (BPEs) were e

SUBMITTER: Yang Q 

PROVIDER: S-EPMC10722922 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature