Integrin α₅β₁ contributes to cell fusion and inflammation mediated by SARS-CoV-2 spike via RGD-independent interaction.

ABSTRACT: The Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus infects host cells by engaging its spike (S) protein with human ACE2 receptor. Recent studies suggest the involvement of integrins in SARS-CoV-2 infection through interaction with the S protein, but the underlying mechanism is not well understood. This study investigated the role of integrin α₅β₁, which recognizes the Arg-Gly-Asp (RGD) motif in its physiological ligands, in S-mediated virus entry and cell-cell fusion. Our results showed that α₅β₁ does not directly contribute to S-mediated cell entry, but it enhances S-mediated cell-cell fusion in collaboration with ACE2. This effect cannot be inhibited by the putative α₅β₁ inhibitor ATN-161 or the high-af

SUBMITTER: Zhang H 

PROVIDER: S-EPMC10723138 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature