Facilitating Ir-Catalyzed C-H Alkynylation with Electrochemistry: Anodic Oxidation-Induced Reductive Elimination.

ABSTRACT: An electrochemical approach in promoting directed C-H alkynylation with terminal alkyne via iridium catalysis is reported. This work employed anodic oxidation of Ir(III) intermediate (characterized by X-ray crystallography) to promote reductive elimination, giving the desired coupling products in good yields (up to 95%) without the addition of any other external oxidants. This transformation is suitable for various directing groups with H₂ as the only by-product, which warrants a high atom economy and practical oxidative C-C bond formation under mild conditions.

SUBMITTER: Ye X 

PROVIDER: S-EPMC10723742 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature