Sex differences in the effects of trait anxiety and age on resting-state functional connectivities of the amygdala.

ABSTRACT:

Background

Numerous studies characterized how resting-state functional connectivities (rsFCs) of the amygdala were disrupted in emotional disorders and varied with emotional traits, including anxiety. With trait anxiety known to diminish with age, a critical issue concerns disambiguating the effects of age and anxiety on amygdala rsFCs in studying the neural bases of individual differences in anxiety.

Methods

Two-hundred adults (83 women) 19-85 years of age underwent fMRI and assessment for trait anxiety. Amygdala rsFC correlates were identified using multiple regression with age and anxiety in the same model for all and separately in men and women. The rsFC correlates were examined for age-anxiety interaction.

Results

Anxiety was negatively correlated with amygdala-t

SUBMITTER: Chaudhary S 

PROVIDER: S-EPMC10723810 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature