Improved oxygenation in prone positioning of mechanically ventilated patients with COVID-19 acute respiratory distress syndrome is associated with decreased pulmonary shunt fraction: a prospective multicenter study.

ABSTRACT:

Background

Prone position is used in acute respiratory distress syndrome and in coronavirus disease 2019 (Covid-19) acute respiratory distress syndrome (ARDS). However, physiological mechanisms remain unclear. The aim of this study was to determine whether improved oxygenation was related to pulmonary shunt fraction (Q's/Q't), alveolar dead space (Vd/Vtalv) and ventilation/perfusion mismatch (V'_A/Q').

Methods

This was an international, prospective, observational, multicenter, cohort study, including six intensive care units in Sweden and Poland and 71 mechanically ventilated adult patients.

Results

Prone position increased PaO₂:FiO₂ after 30 min, by 78% (83-148 mm Hg). The effect persisted 120 min after return to supine (p < 0.001). Th

SUBMITTER: Harbut P 

PROVIDER: S-EPMC10725003 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature