Quantifying tissue properties and absolute hemodynamics using coherent spatial imaging.

ABSTRACT:

Significance

Measuring hemodynamic function is crucial for health assessment. Optical signals provide relative hemoglobin concentration changes, but absolute measurements require costly, bulky technology. Speckleplethysmography (SPG) uses coherent light to detect speckle fluctuations. Combining SPG with multispectral measurements may provide important physiological information on blood flow and absolute hemoglobin concentration.

Aim

To develop an affordable optical technology to measure tissue absorption, scattering, hemoglobin concentrations, tissue oxygen saturation (StO2), and blood flow.

Approach

We integrated reflectance spectroscopy and laser speckle imaging to create coherent spatial imaging (CSI). CSI was validated against spatial frequency domain imaging (SFD

SUBMITTER: Crouzet C 

PROVIDER: S-EPMC10730023 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature