Sex differences in the survival benefit of kidney transplantation: a retrospective cohort study using target trial emulation.

ABSTRACT:

Background

Kidney transplantation is the preferred treatment for eligible patients with kidney failure who need renal replacement therapy. However, it remains unclear whether the anticipated survival benefit from kidney transplantation is different for women and men.

Methods

We included all dialysis patients recorded in the Austrian Dialysis and Transplant Registry who were waitlisted for their first kidney transplant between 2000 and 2018. In order to estimate the causal effect of kidney transplantation on 10-year restricted mean survival time, we mimicked a series of controlled clinical trials and applied inverse probability of treatment and censoring weighted sequential Cox models.

Results

This study included 4408 patients (33% female) with a mean age of 52 years.

SUBMITTER: Geroldinger A 

PROVIDER: S-EPMC10730810 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature