Comparison between a novel salivary marker and several clinical prognosticators in oral cavity cancer.

ABSTRACT:

Objectives

This study aimed to investigate the association between salivary matrix metalloproteinase-1 (MMP-1) and clinicopathological parameters of oral cavity squamous cell carcinoma (OSCC) and compare the prognostic efficacy of salivary MMP-1 and other established circulating markers for OSCC.

Methods

Saliva specimens from 479 OSCC subjects were examined using an enzyme-linked immunosorbent assay. The area under the curve (AUC) values of salivary MMP-1 and other markers were calculated, and survival analyses were conducted using Kaplan-Meier and multivariate regression methods.

Results

Salivary MMP-1 showed good discrimination in predicting overall survival, with an AUC of 0.638, which was significantly higher than that of albumin (0.530, p = .021) and Charl

SUBMITTER: Lee YC 

PROVIDER: S-EPMC10731513 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature