Dataset Information

Genomic, transcriptomic, and phenotypic differences among archetype Shigella flexneri strains of serotypes 2a, 3a, and 6.

ABSTRACT:

Importance

Given the genomic diversity between S. flexneri serotypes and the paucity of data to support serotype-specific phenotypic differences, we applied in silico and in vitro functional analyses of archetype strains of 2457T (Sf2a), J17B (Sf3a), and CH060 (Sf6). These archetype strains represent the three leading S. flexneri serotypes recommended for inclusion in multivalent vaccines. Characterizing the genomic and phenotypic variation among these clinically prevalent serotypes is an important step toward understanding serotype-specific host-pathogen interactions to optimize the efficacy of multivalent vaccines and therapeutics. This study underpins the importance for further large-scale serotype-targeted analyses.

SUBMITTER: Gabor CE

PROVIDER: S-EPMC10732043 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Publications

Genomic, transcriptomic, and phenotypic differences among archetype Shigella flexneri strains of serotypes 2a, 3a, and 6.

Gabor Caitlin E CE Hazen Tracy H TH Delaine-Elias BreOnna C BC Rasko David A DA Barry Eileen M EM

mSphere 20231013 6

<h4>Importance</h4>Given the genomic diversity between S. flexneri serotypes and the paucity of data to support serotype-specific phenotypic differences, we applied in silico and in vitro functional analyses of archetype strains of 2457T (Sf2a), J17B (Sf3a), and CH060 (Sf6). These archetype strains represent the three leading S. flexneri serotypes recommended for inclusion in multivalent vaccines. Characterizing the genomic and phenotypic variatio ...[more]

PMID: 37830809

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Dataset Information

Genomic, transcriptomic, and phenotypic differences among archetype Shigella flexneri strains of serotypes 2a, 3a, and 6.

Importance

Publications

Genomic, transcriptomic, and phenotypic differences among archetype <i>Shigella flexneri</i> strains of serotypes 2a, 3a, and 6.

Similar Datasets

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