SplicingLore: a web resource for studying the regulation of cassette exons by human splicing factors.

ABSTRACT: One challenge faced by scientists from the alternative RNA splicing field is to decode the cooperative or antagonistic effects of splicing factors (SFs) to understand and eventually predict splicing outcomes on a genome-wide scale. In this manuscript, we introduce SplicingLore, an open-access database and web resource that help to fill this gap in a straightforward manner. The database contains a collection of RNA-sequencing-derived lists of alternative exons regulated by a total of 75 different SFs. All datasets were processed in a standardized manner, ensuring valid comparisons and correlation analyses. The user can easily retrieve a factor-specific set of differentially included exons from the database or provide a list of exons and search which SF(s) control(s) their inclusion. Our sim

SUBMITTER: Polveche H 

PROVIDER: S-EPMC10735282 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature