Rank aggregation of independent genetic screen results highlights new strategies for adoptive cellular transfer therapy of cancer.

ABSTRACT: Efficient intratumoral infiltration of adoptively transferred cells is a significant barrier to effectively treating solid tumors with adoptive cellular transfer (ACT) therapies. Our recent forward genetic, whole-genome screen identified T cell-intrinsic gene candidates that may improve tumor infiltration of T cells. Here, results are combined with five independent genetic screens using rank aggregation to improve rigor. This resulted in a combined total of 1,523 candidate genes - including 1,464 genes not currently being evaluated as therapeutic targets - that may improve tumor infiltration of T cells. Gene set enrichment analysis of a published human dataset shows that these gene candidates are differentially expressed in tumor infiltrating compared to circulating T cells, supporting tra

SUBMITTER: Vianzon VV 

PROVIDER: S-EPMC10748423 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature