The Role and Potential Mechanism of Complement Factor D in Fibromyalgia Development.

ABSTRACT:

Purpose

Fibromyalgia (FM) is a syndrome characterized by chronic musculoskeletal pain. Its clinical symptoms include both somatic and psychiatric symptoms, making the treatment of FM extremely challenging. The cause of FM is still unknown, and some patients do not improve their symptoms even after long-term active treatment. Thus, the development of new targeted therapies is important to reduce pain and improve quality of life for FM patients.

Methods

In this study, we screened genes and secreted factors that play key roles in FM through bioinformatics and big data analysis. Furthermore, we performed CCK-8, qRT-PCR, glucose, ATP and lactate content testing, dual luciferase reporter gene assay to investigate the potential mechanism of complement factor D in fibromyalgia devel

SUBMITTER: Lei X 

PROVIDER: S-EPMC10748666 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature