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Novel Insights into Prokineticin 1 Role in Pregnancy-related Diseases.

ABSTRACT: Prokineticin 1 (PROK1) is a secreted protein involved in a range of physiological activities such as cell proliferation, migration, angiogenesis, and neuronal cell proliferation. Emerging evidences show that PROK1/PROK receptors (PROKRs) are expressed by trophoblasts, and decidual stroma cells at the maternal-fetal interface. PROK1 plays a critical role in successful pregnancy establishment by regulating the decidualization, implantation and placental development. Dysregulation of prokineticin signaling has been described in certain pathological states associated with pregnancy, including pre-eclampsia, recurrent miscarriage and fetal growth restriction. In this review, the expression and pleiotropic roles of PROK1 under physiological and pathological pregnancy conditions are discussed.

SUBMITTER: Cheng XX

PROVIDER: S-EPMC10750342 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

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Novel Insights into Prokineticin 1 Role in Pregnancy-related Diseases.

Cheng Xi-Xi XX Li Ming-Qing MQ Peng Ting T

International journal of medical sciences 20240101 1

Prokineticin 1 (PROK1) is a secreted protein involved in a range of physiological activities such as cell proliferation, migration, angiogenesis, and neuronal cell proliferation. Emerging evidences show that PROK1/PROK receptors (PROKRs) are expressed by trophoblasts, and decidual stroma cells at the maternal-fetal interface. PROK1 plays a critical role in successful pregnancy establishment by regulating the decidualization, implantation and placental development. Dysregulation of prokineticin s ...[more]

PMID: 38164347

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