Cha o 3, a cypress pollen allergen, does not activate basophils in Japanese cypress pollinosis.

ABSTRACT:

Background

In Japan, pollinosis caused by the Japanese cypress (JCy) Chamaecyparis obtusa is among the very common seasonal allergies. In JCy pollinosis, Cha o 1 is the first major allergen, and Cha o 2 is the second major allergen. Recently, Cha o 3 was identified as a new JCy pollen allergen in JCy pollinosis. However, the relative contribution of Cha o 3 to JCy pollinosis compared with that of Cha o 1 and that of Cha o 2 has not been fully elucidated.

Objective

This study aimed to clarify the allergenicity of Cha o 3 compared with that of Cha o 1 and Cha o 2 in JCy pollinosis.

Methods

We recruited 27 patients with JCy pollinosis and performed the basophil activation test (BAT) with native (n) Cha o 1, Cha o 2, and Cha o 3 purified from JCy pollen. In additio

SUBMITTER: Kobayashi Y 

PROVIDER: S-EPMC10753085 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature