Biventricular intraventricular mechanical and electrical dyssynchrony in pulmonary arterial hypertension.

ABSTRACT:

Background

Pulmonary arterial hypertension (PAH) leads to myocardial remodeling, manifesting as mechanical dyssynchrony (M-dys) and electrical dyssynchrony (E-dys), in both right (RV) and left ventricles (LV). However, the impacts of layer-specific intraventricular M-dys on biventricular functions and its association with E-dys in PAH remain unclear.

Methods

Seventy-nine newly diagnosed patients with PAH undergoing cardiac magnetic resonance scanning were consecutively recruited between January 2011 and December 2017. The biventricular volumetric and layer-specific intraventricular M-dys were analyzed. The QRS duration z-scores were calculated after adjusting for age and sex.

Results

77.22 % of patients were female (mean age 30.30 ± 9.79 years; median follow-up

SUBMITTER: Li W 

PROVIDER: S-EPMC10755332 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature