The Contribution of DNA Ligase 4 Polymorphisms to Colorectal Cancer.

ABSTRACT:

Background/aim

While numerous biomarkers associated with genetic susceptibility to colorectal cancer (CRC) have been identified and validated through epidemiological studies, the specific influence of DNA ligase 4 (Lig4) genotypes remains unexplored. This study aimed to elucidate the hitherto unexamined relationship between Lig4 genotypes and CRC risk.

Materials and methods

The genotypes of Lig4 rs1805388 were determined applying the polymerase chain reaction-restriction fragment length polymorphism methodology. The potential association between these genotypes and CRC risk was assessed in a Taiwanese population comprising 362 CRC cases and an equal number of age- and sex-matched controls.

Results

In the genotypic analysis, the distribution of CC, CT, and TT genotypes

SUBMITTER: Deng Y 

PROVIDER: S-EPMC10756467 | biostudies-literature | 2024 Jan-Feb

REPOSITORIES: biostudies-literature