Association of gut microbiota with portal vein pressure in patients with liver cirrhosis undergoing living donor liver transplantation.

ABSTRACT:

Background and aim

Many recent studies have shown a relationship between various systemic diseases and the gut microbiota (GM), with the gut-liver axis receiving particular attention. In contrast, no report has comprehensively shown the effects of GM on the pathophysiology of patients undergoing living donor liver transplantation (LDLT).

Method

We enrolled 16 recipients who underwent LDLT for liver cirrhosis, and 17 donors constituted the reference group. We examined the differences in GM between recipients and donors. We also examined the relationships between GM, short-chain fatty acids, and portal vein pressure (PVP) in recipients.

Results

There was no significant difference in alpha-diversity between the recipients and donors, but there was variation in beta-diver

SUBMITTER: Toshida K 

PROVIDER: S-EPMC10757484 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature