Pericyte loss initiates microvascular dysfunction in the development of diastolic dysfunction.

ABSTRACT:

Aims

Microvascular dysfunction has been proposed to drive heart failure with preserved ejection fraction (HFpEF), but the initiating molecular and cellular events are largely unknown. Our objective was to determine when microvascular alterations in HFpEF begin, how they contribute to disease progression, and how pericyte dysfunction plays a role herein.

Methods and results

Microvascular dysfunction, characterized by inflammatory activation, loss of junctional barrier function, and altered pericyte-endothelial crosstalk, was assessed with respect to the development of cardiac dysfunction, in the Zucker fatty and spontaneously hypertensive (ZSF1) obese rat model of HFpEF at three time points: 6, 14, and 21 weeks of age. Pericyte loss was the earliest and strongest microvascula

SUBMITTER: Simmonds SJ 

PROVIDER: S-EPMC10763525 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature