Comprehensive reference intervals for white blood cell counts during pregnancy.

ABSTRACT:

Background

White blood cell (WBC) count increases during pregnancy, necessitating reliable reference intervals for assessing infections and pregnancy-related complications. This study aimed to establish comprehensive reference intervals for WBC counts during pregnancy.

Methods

The analysis included 17,737 pregnant women, with weekly WBC count measurements from pre-pregnancy to postpartum. A threshold linear regression model determined reference intervals, while Harris and Boyd's test partitioned the intervals.

Results

WBC count exhibited a significant increase during pregnancy, characterized by a rapid rise before 7 weeks of gestation, followed by a plateau. Neutrophils primarily drove this increase, showing a similar pattern. The threshold regression model and Harris

SUBMITTER: Zhu J 

PROVIDER: S-EPMC10768452 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature