Septin9 DNA methylation is associated with breast cancer recurrence or metastasis.

ABSTRACT:

Objective

We aimed to explore the prognostic value of Septin9 DNA methylation in breast cancer.

Methods

Breast cancer patients with and without recurrence or metastasis and matched non-breast cancer patients were screened retrospectively from 2014 to 2016. Bisulfite conversion and fluorescence quantitative methylation-specific polymerase chain reaction were used to detect the Septin9 methylation status and distribution levels in patient breast tissues.

Results

Septin9 DNA methylation was more frequent in breast cancer tissues than in non-breast cancer tissues, but was not significantly correlated with any relevant breast cancer patient clinicopathological characteristic. Septin9 methylation rates were higher in patients with recurrence or m

SUBMITTER: Zhang SL 

PROVIDER: S-EPMC10771060 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature