Exogenous l-fucose attenuates neuroinflammation induced by lipopolysaccharide.

ABSTRACT: α1,6-Fucosyltransferase (Fut8) catalyzes the transfer of fucose to the innermost GlcNAc residue of N-glycan to form core fucosylation. Our previous studies showed that lipopolysaccharide (LPS) treatment highly induced neuroinflammation in Fut8 homozygous KO (Fut8^-/-) or heterozygous KO (Fut8^+/-) mice, compared with the WT (Fut8^+/+) mice. To understand the underlying mechanism, we utilized a sensitive inflammation-monitoring mouse system that contains the human interleukin-6 (hIL6) bacterial artificial chromosome transgene modified with luciferase (Luc) reporter cassette. We successfully detected LPS-induced neuroinflammation in the central nervous system by exploiting this bacterial artificial chromosome transgenic monitoring system. Then we examined the ef

SUBMITTER: Xu X 

PROVIDER: S-EPMC10772726 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature