Population genomics of post-glacial western Eurasia.

ABSTRACT: Western Eurasia witnessed several large-scale human migrations during the Holocene^1-5. Here, to investigate the cross-continental effects of these migrations, we shotgun-sequenced 317 genomes-mainly from the Mesolithic and Neolithic periods-from across northern and western Eurasia. These were imputed alongside published data to obtain diploid genotypes from more than 1,600 ancient humans. Our analyses revealed a 'great divide' genomic boundary extending from the Black Sea to the Baltic. Mesolithic hunter-gatherers were highly genetically differentiated east and west of this zone, and the effect of the neolithization was equally disparate. Large-scale ancestry shifts occurred in the west as farming was introduced, including near-total replacement of hunter-gatherers in many areas

SUBMITTER: Allentoft ME 

PROVIDER: S-EPMC10781627 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature